Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia
Tumor BSS Hats tissues are chronically exposed to hypoxia owing to aberrant vascularity.Lipid droplet (LD) accumulation is a hallmark of hypoxic cancer cells, yet how LDs form and function during hypoxia remains poorly understood.Herein, we report that in various cancer cells upon oxygen deprivation, HIF-1 activation down-modulates LD catabolism me